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Add-on accelerated continuous theta burst stimulation (a-cTBS) over the left temporoparietal junction for the management of persistent auditory hallucinations in schizophrenia: A case series

Add-on accelerated continuous theta burst stimulation (a-cTBS) over the left temporoparietal junction for the management of persistent auditory hallucinations in schizophrenia: A case series

Authors: 
Chithra, U., Samantaray, S., Kumar, V., K, R., Maity, K., E, N., Akhtar, K. J., Parlikar, R., Bagali, K. B., Sreeraj, V. S., Shreekantiah, U., Purohith, A. N., Shenoy, S., Praharaj, S. K., Goyal, N., Mehta, U. M., Venkatasubramanian, G., & Thirthalli, J.
Year: 
2022
Journal: 
Brain Stimulation
Abstract: 

Auditory verbal hallucinations (AVH) form one of the cardinal symptoms of schizophrenia with about 65e75% reporting them. Antipsychotics proclaimed to be effective for positive symptoms, fail to bring remission in about 30e40% of individuals reporting auditory hallucinations. Transcranial magnetic stimulation (TMS) owing to its targeted modulation of neural activity has the potential for the treatment of these symptoms. However, the use of conventional TMS protocols has been limited by studies showing small effects, requiring longer time and larger numbers needed to treat (NNT) to demonstrate responses, and having the pragmatic burden of daily hospital visits for availing treatment facilities. Accelerated TMS protocols could address some of these by shortening the treatment duration and thereby increasing the efficiency of standard TMS. Furthermore, studies have demonstrated that higher doses of TMS pulses can be tolerated with no significant side effects. In schizophrenia, cTBS has been examined as an add-on treatment in the management of persistent auditory hallucinations in controlled trials. While accelerated protocols having more than two sessions per day have been described for depression and OCD , it has not been studied in schizophrenia. We report the clinical effects of MRI-guided neuronavigation-based add-on accelerated cTBS (five per day sessions) to the left temporoparietal junction (TPJ) for persistent AVH in schizophrenia

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